ASPA CLIA Kit for Human(Homo sapiens) | EIAab.comASPA CLIA Kit for Human(Homo sapiens)

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ASPA (Gene name),

Aspartoacylase (Protein name ), ACY2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ASPA(ACY2;ASP);

Protein name:

Aspartoacylase;

Alternative:

Aminoacylase-2(ACY-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

313

Sequence:

50:

100:

150:

200:

250:

300:

313:

LTLNAKSIRC | CLH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:443

String:

P45381

MIM:

271900

Pfam:

PF04952

SMR:

P45381

STRING:

9606.ENSP00000263080

UniGene:

Hs.171142

Uniprot:

P45381

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ELISA Kit for Human Aspartoacylase

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ELISA Kit for Human Aspartoacylase

Cat.:

E2260h

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96T

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ELISA Kit for Human Aspartoacylase

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E2260m

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96T

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ELISA Kit for Human Aspartoacylase

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E2260r

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96T

ELISA Kit for Human Aspartoacylase

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E2260p

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96T

CLIA Kit for Human Aspartoacylase

Cat.:

U2260m

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96T

CLIA Kit for Human Aspartoacylase

Cat.:

U2260h

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96T

CLIA Kit for Human Aspartoacylase

Cat.:

U2260b

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96T

CLIA Kit for Human Aspartoacylase

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U2260r

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96T

CLIA Kit for Human Aspartoacylase

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U2260p

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96T

Polyclonal Antibody for Human Aspartoacylase

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P2260Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Aspartoacylase

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P2260Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Aspartoacylase

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P2260Rb-h

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Polyclonal Antibody for Human Aspartoacylase

Monoclonal Antibody for Human Aspartoacylase

Protein for Human Aspartoacylase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease."
Kaul R. , Gao G.P. , Balamurugan K. , Matalon R.
Nat. Genet.5:118-123(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT CAND ALA-285
tissue: Kidney.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
3.

"Purification and preliminary characterization of brain aspartoacylase."
Moore R.A. , Le Coq J. , Faehnle C.R. , Viola R.E.
Arch. Biochem. Biophys.413:1-8(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;CHARACTERIZATION OF VARIANT CAND ALA-285;MUTAGENESIS OF GLU-285
tissue: Brain.
4.

"Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease."
Herga S. , Berrin J.G. , Perrier J. , Puigserver A. , Giardina T.
FEBS Lett.580:5899-5904(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ZINC-BINDING SITES;ACTIVE SITE;MUTAGENESIS OF GLU-178
5.

"Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue."
Le Coq J. , Pavlovsky A. , Malik R. , Sanishvili R. , Xu C. , Viola R.E.
Biochemistry47:3484-3492(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) IN COMPLEXES WITH ZINC IONS; PHOSPHATE AND N-PHOSPHONOMETHYL-L-ASPARTATE;COFACTOR;SUBUNIT;MUTAGENESIS OF ARG-71; TYR-164; ARG-168; GLU-178 AND TYR-288
6.

"Structure of aspartoacylase, the brain enzyme impaired in Canavan disease."
Bitto E. , Bingman C.A. , Wesenberg G.E. , McCoy J.G. , Phillips G.N. Jr.
Proc. Natl. Acad. Sci. U.S.A.104:456-461(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH ZINC IONS;SUBUNIT;COFACTOR
7.

"Canavan disease: mutations among Jewish and non-Jewish patients."
Kaul R. , Gao G.P. , Aloya M. , Balamurugan K. , Petrosky A. , Michals K. , Matalon R.
Am. J. Hum. Genet.55:34-41(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND ALA-285 AND GLU-305
8.

"The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients."
Shaag A. , Anikster Y. , Christensen E. , Glustein J.Z. , Fois A. , Michelakakis H. , Nigro F. , Pronicka E. , Ribes A. , Zabot M.-T. , Elpeleg O.N.
Am. J. Hum. Genet.57:572-580(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND 176-GLY-ILE-177 DEL; ARG-274; SER-295 AND GLU-305
9.

"Novel (Cys152 > Arg) missense mutation in an Arab patient with Canavan disease."
Kaul R. , Gao G.P. , Michals K. , Whelan D.T. , Levin S. , Matalon R.
Hum. Mutat.5:269-271(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAND ARG-152
10.

"Identification and expression of eight novel mutations among non-Jewish patients with Canavan disease."
Kaul R. , Gao G.P. , Matalon R. , Aloya M. , Su Q. , Jin M. , Johnson A.B. , Schutgens R.B.H. , Clarke J.T.R.
Am. J. Hum. Genet.59:95-102(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND THR-16; ARG-27; GLU-114; GLU-123; TYR-152; CYS-168; ALA-285 AND GLU-305;VARIANT GLY-310;CHARACTERIZATION OF VARIANTS CAND THR-16; ARG-27; GLU-114; GLU-123; TYR-152 AND CYS-168
11.

"Missense mutation (I143T) in a Japanese patient with Canavan disease."
Kobayashi K. , Tsujino S. , Ezoe T. , Hamaguchi H. , Nihei K. , Sakuragawa N.
Hum. Mutat. Suppl.1:S308-S309(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAND THR-143
12.

"Novel missense mutation (Y231C) in a Turkish patient with Canavan disease."
Rady P.L. , Vargas T. , Tyring S.K. , Matalon R. , Langenbeck U.
Am. J. Med. Genet.87:273-275(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAND CYS-231
13.

"The spectrum of mutations of the aspartoacylase gene in Canavan disease in non-Jewish patients."
Elpeleg O.N. , Shaag A.
J. Inherit. Metab. Dis.22:531-534(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND THR-16; ARG-27; HIS-183; PHE-186; ARG-195; ARG-274; SER-280; LEU-280; THR-287; SER-295 AND GLU-305
14.

"Mutation detection in the aspartoacylase gene in 17 patients with Canavan disease: four new mutations in the non-Jewish population."
Sistermans E.A. , de Coo R.F. , van Beerendonk H.M. , Poll-The B.T. , Kleijer W.J. , van Oost B.A.
Eur. J. Hum. Genet.8:557-560(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND PRO-21; THR-57; HIS-168 AND THR-181
15.

"Identification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease."
Zeng B.J. , Wang Z.H. , Ribeiro L.A. , Leone P. , De Gasperi R. , Kim S.J. , Raghavan S. , Ong E. , Pastores G.M. , Kolodny E.H.
J. Inherit. Metab. Dis.25:557-570(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND GLY-24; ALA-68; TRP-152; ARG-244 AND VAL-249
16.

"Two novel aspartoacylase gene (ASPA) missense mutations specific to Norwegian and Swedish patients with Canavan disease."
Olsen T.R. , Tranebjaerg L. , Kvittingen E.A. , Hagenfeldt L. , Moller C. , Nilssen O.
J. Med. Genet.39:E55-E55(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CAND TYR-114 AND VAL-249

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